MW:50,000bySDSPAGE
ExtinctionCoefficient:0.70
Lyophilizedfrom20mMTris,20mMNaCl,pH7.5
Storage:-20°C
BuyPurifiedNativeHumanLRG1,Leucine-richAlpha2Glycoprotein-1,HumanPlasma,$110.00/50ug.BulkQtyAvailable.
InnormalplasmaLRG1hasaconcentrationof21-50ug/ml.Itisanacutephaseproteinwithlevelselevatedinpatientswithbacterialinfections;interestingly,duringtheinflammatoryresponse,LRG1levelsarenotcorrelatedwithCRPlevels.
LRG1bindscytochromec,aninitiator/amplifierofprogrammedcelldeath(apoptosis),andbybindingcytochromec,isthoughttoplayaroleincellsurvival.
LRG1isabioMarkerassociatedwithseveralcancers,includingnon-smallcelllungcancer,colorectalcancer,andpancreaticcancer.Recentstudieshaveshownitisthree-foldmoreabundantinovariancancerserumcomparedtonon-cancercontrolserum.LRG1levelsareonlymoderatelycorrelatedwithCA125levels.
ElevatedlevelsofLRG1incerebralspinalfluidarebeingstudiedasmarkersfortheearlydiagnosisofParkinsonsdiseaseandprogressivesupranuclearpalsy.
Purity:>=95%bySDS-PAGE.Positivereactiontoanti-LRG1onWesternBlot.
PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.
AthensResearch&Technologyproductsarelaboratoryreagentsandarenottobeadministeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.