MW:50,000bySDSPAGE
ExtinctionCoefficient:0.70

Lyophilizedfrom20mMTris,20mMNaCl,pH7.5

Storage:-20°C

BuyPurifiedNativeHumanLRG1,Leucine-richAlpha2Glycoprotein-1,HumanPlasma,$110.00/50ug.BulkQtyAvailable.

InnormalplasmaLRG1hasaconcentrationof21-50ug/ml.Itisanacutephaseproteinwithlevelselevatedinpatientswithbacterialinfections;interestingly,duringtheinflammatoryresponse,LRG1levelsarenotcorrelatedwithCRPlevels.

LRG1bindscytochromec,aninitiator/amplifierofprogrammedcelldeath(apoptosis),andbybindingcytochromec,isthoughttoplayaroleincellsurvival.

LRG1isabioMarkerassociatedwithseveralcancers,includingnon-smallcelllungcancer,colorectalcancer,andpancreaticcancer.Recentstudieshaveshownitisthree-foldmoreabundantinovariancancerserumcomparedtonon-cancercontrolserum.LRG1levelsareonlymoderatelycorrelatedwithCA125levels.

ElevatedlevelsofLRG1incerebralspinalfluidarebeingstudiedasmarkersfortheearlydiagnosisofParkinsonsdiseaseandprogressivesupranuclearpalsy.

Purity:>=95%bySDS-PAGE.Positivereactiontoanti-LRG1onWesternBlot.

PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&Technologyproductsarelaboratoryreagentsandarenottobeadministeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.