Aptamers: Catalogue Aptamers

Interferon gamma (IFNγ)is a dimerized soluble cytokine that is the only member of the type II class of interferons and is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. IFNγ is an important activator of macrophages. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects.

Target: IFN Gamma

Target Species: bovine

Target Type: protein

Affinity Constant (Kd): 33.7 nM

Default 3" Linker (Spacer) is 10T. Please submit a custom quote request for other options.

This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and Bovine IFNγ [GenWay Biotech Inc. Cat. #GWB-0F0115] as a target and 1X PBS, pH 7.4, 1 mM MgCl2. Let us know if you have any questions about its development or potential uses.

Aptamer informationKd 33.7 ± 6.0 nM

Datasheet

Please choose your modification and add as an extra catalogue number:ATWUNMOD - UnmodifiedATWAMINE - Amine modificationATWBIOTIN - Biotin modificationATWTHIOL - Thiol modification (extra charge)ATWFLUOR - Fluor (all) modification (extra charge)

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

Antibody Equivalent Units (AEU). There is a large molecular weight difference in antibodies (typically 150,000 Da) and Base Pair’s aptamers (~14,000 Da). We provide our aptamers in terms of moles, where the aptamer moles in 1 AEU is equal to antibody moles in the typical 100 microgram shipment from a leading antibody vendor. Therefore our standard 2.5 AEU (25ug) or 5 AEU (50ug) delivery is 2.5 and 5 times the equivalent moles of a standard antibody delivery of 100 microgram respectively.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200